Sustainable intensification of mixed crop livestock systems is a key pathway towards better food security, improved livelihoods and a healthy environment. As part of the US government’s Feed the Future initiative to address hunger and food security issues in sub-Saharan Africa, the US Agency for International Development (USAID) is supporting three multi-stakeholder agricultural research projects to sustainably intensify key African farming systems. In East and Southern Africa the project is being implemented in Tanzania and Malawi, and Zambia. – In Tanzania the project is being implemented in Babati and Kongwadistricts in Manyara region of northern Tanzania and Kiteto district in Dodoma region, central Tanzania. The action sites were selected to acknowledge agroecological differences, allow appropriate targeting of technologies and strategies, and complement the development efforts of another USAID-supported program, the Tanzania Staples Value Chain (NAFAKA) project. – In Malawi, the project is being implemented in Ntechu and Dedza districts in central Malawi where maize-based productions systems are dominant. Agroecological considerations guided the identification of research action sites. – The pilot site for the study will be Eastern and Lusaka Provinces in Zambia.